Studies on the changes of glomerular permeability in proteinuria.

The view is wildly held currently that renal proteinuria is primarily the results of increased permeability of glomerular capillary membrane(1,2,3,4). The purpose of this paper is to study the passway of high molecular substance through the glomerular capillary membrane and the permeability of that membrane in renal diseases. This study was not so easy, because urinary protein contents, which was able to be determined by our routine work, were exceedingly modified by tubular reabsorption and we are hardly to know the true protein contents in the glomerular filtrate. For this study, we used the isolated rabbit's kidney perfusion technique and Dextran preparation in the clearance method in order to exclude the effect of tubular reabsorption.